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A 36-year-old member asked:

What is the main substance found in pumpkins that causes people to be allergic?

1 doctor answer2 doctors weighed in
Dr. Michael Zacharisen
Allergy and Immunology 34 years experience
Pumpkin allergy: Pumpkin allergy is rare or rarely reported with about 5 cases. The antigen (or allergen) can be in the rind, seed or flesh. In the pumpkin flesh, the allergen was a protein size ranging from 20 to 225 kda in at least in 1 patient. These proteins are called profilins or ltp (lipid transfer proteins). There is cross-reactivity between pumpkin, muskmelon, watermelon, cucumber, and zucchini.

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Last updated Jan 31, 2013

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