A member asked:

In early stages of connective tissue disease, is it possible to have inflammation that responds great 2 prednisone but doesn't show up in sed or crp?

A doctor has provided 1 answer
Dr. Thomas Namey answered

Specializes in Rheumatology

Yes: The typical inflammation in sytemic lupus erythematosis may not elevate these acute phase reactants. That being said, Prednisone is an energizer and can improve many types of discomfort or pain. There are other tests more valuable than ESR and crp.

Answered 6/30/2014

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