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A 54-year-old female asked:

Why is my sed,crp normal even with pleurisy and swollen joints and prednisone is only thing that helps? sle. why does it not pick up on the inflamm?

1 doctor answer3 doctors weighed in
Dr. Ed Friedlander
Pathology 45 years experience
No easy answer: Please forgive me. Sed rate and C-reactive protein are famously unreliable markers for inflammation in lupus and suspected lupus. A different pathway of inflammation is often involved. Despite "pop" ideas about "inflammation", inflammation enormously complicated. If it weren't, common painkillers would clear depression, which some folks describe as "a form of inflammation."

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Last updated Jul 18, 2015

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