A member asked:

If the man has the sicklecell trait, do that mean all his children will have the trait too?

A doctor has provided 1 answer

No: Sickle cell trait means that one is a "carrier" of the sickle cell gene. It takes two copies of the sickle cell gene to manifest sickle cell disease. If a man has sickle cell trait, he may pass the sickle cell gene or the normal gene to his offspring - meaning 50% risk that he will pass on the sickle cell gene. The offspring's chance of inheritance also depends on the status of the mother!

Answered 3/2/2019

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