What is better for fibromyalgia: cyclobenzaprine or lyrica (pregabalin)?

Lyrica, (pregabalin) probably: Lyrica (pregabalin), Cymbalta (duloxetine), and savella (milnacipran) are fda approved for fibromyalgia, although other medications including Flexeril (cyclobenzaprine hcl) (cyclobenzaprine) have also been proven to help the symptoms. I am not aware of any studies directly comparing cyclobenzaprine with lyrica, but Lyrica has more data supporting its efficacy than does cyclobenzaprine.

It depends: Every fibromyalgia patient is different and a medicine that works for one patient may not work for another. Cyclobenzaprine (flexeril) is a muscle relaxant that belongs to a class of drugs called the tricyclic antidepressants. Lyrica (pregabalin) is a seizure medicine that is also used to treat pain. While many patients benefit from these medicines, others don't tolerate them. You will have to try.