A member asked:

What is better for fibromyalgia: cyclobenzaprine or lyrica (pregabalin)?

4 doctors weighed in across 2 answers
Dr. Shaym Puppala answered

Specializes in Internal Medicine

Lyrica, (pregabalin) probably: Lyrica (pregabalin), Cymbalta (duloxetine), and savella (milnacipran) are fda approved for fibromyalgia, although other medications including Flexeril (cyclobenzaprine hcl) (cyclobenzaprine) have also been proven to help the symptoms. I am not aware of any studies directly comparing cyclobenzaprine with lyrica, but Lyrica has more data supporting its efficacy than does cyclobenzaprine.

Answered 12/31/2014


Dr. Chad Boomershine answered

Specializes in Rheumatology

It depends: Every fibromyalgia patient is different and a medicine that works for one patient may not work for another. Cyclobenzaprine (flexeril) is a muscle relaxant that belongs to a class of drugs called the tricyclic antidepressants. Lyrica (pregabalin) is a seizure medicine that is also used to treat pain. While many patients benefit from these medicines, others don't tolerate them. You will have to try.

Answered 8/22/2015



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