A member asked:

What is more sedative out of amitryptiline and mirtazapine? and which one causes more grogginess the next day? many thanks.

10 doctors weighed in across 4 answers
Dr. Douglas Bey answered

Specializes in Psychiatry

Remeron (mirtazapine) max dose is 45 mg Elavil may b 300 mg (depending on liver function & blood level of the drug. The lowest dose of Remeron (mirtazapine) (15mg) tends to b more sedating than the higher doses because it doesn't start raising norepinephrine until 30 mg and this has a stimulating. Effect that counters some of the sedation. Both Remeron (mirtazapine) & Elavil should b taken a couple hrs before bedtime to reduce hangover.

Answered Nov 7, 2014

5.4k views

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Dr. David Simons answered

Specializes in Anesthesiology

Both are antidepressants with sedative properties that may last for extended periods of time - this effect is tolerated differently by each patient. If you are using this medication only as a sleep aide other medications may be less sedating (like ambien).

Answered May 3, 2016

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Dr. Alan Ali answered

Specializes in Psychiatry

This depends on the dose and your tolerance. Remeron (mirtazapine) has longer half life though.

Answered Jun 30, 2014

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Dr. Jeffrey Satinover answered

Specializes in Psychiatry

Elavil is more predictably sedating, Remeron (mirtazapine) can be and is for some people, not for others. Remeron (mirtazapine) is a more complex medication in that respect. So it's best to try things out and experiment a bit, under expert supervision, of course!

Answered Nov 28, 2017

5.3k views

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