A member asked:

What is the definition or description of: monoclonal gammopathy of undetermined significance?

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Dr. Michael Dugan answered

Specializes in Hematology

A monoclonal: Gammopathy is an elevation in a specific type of immune protein in the blood. The work-up includes tests of urine protein, bones and blood production. If no serious associated disease is found then the clinical finding is called mgus. The patient is followed over time to see if the gammopathy becomes "significant." some patients declare themselves later with multiple myemoma or lymphoma.

Answered 6/7/2019

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See below: Increased immunoglobulin ( antibody) level in small amounts from single clone of plama cells ( present in bone marrow) in small amounts without causing any symptoms unlike in multiple myeloma.

Answered 1/12/2013

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