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A 28-year-old male asked:

What is the definition or description of: monoclonal gammopathy of undetermined significance?

2 doctor answers2 doctors weighed in
Dr. Michael Dugan
Specializes in Hematology
A monoclonal: Gammopathy is an elevation in a specific type of immune protein in the blood. The work-up includes tests of urine protein, bones and blood production. If no serious associated disease is found then the clinical finding is called mgus. The patient is followed over time to see if the gammopathy becomes "significant." some patients declare themselves later with multiple myemoma or lymphoma.
Dr. Alok Agrawal
Nephrology and Dialysis 34 years experience
See below: Increased immunoglobulin ( antibody) level in small amounts from single clone of plama cells ( present in bone marrow) in small amounts without causing any symptoms unlike in multiple myeloma.

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A 47-year-old member asked:

What's monoclonal gammopathy of undetermined significance?

1 doctor answer1 doctor weighed in
Dr. Ahmad M Hadied
Orthopedic Surgery 49 years experience
MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein.Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition.
A 48-year-old member asked:

Can i treat a possible monoclonal gammopathy of undetermined significance at home?

1 doctor answer1 doctor weighed in
Dr. Carlos Encarnacion
Medical Oncology 35 years experience
Nope: You don't treat an mgus, it is a condition that can ultimately lead to multiple myeloma (risk is about 1% per year) but as of itself does not need therapy (assuming it was correctly diagnosed). You need to have labs checked at least 1 or 2 times a year so you should follow up with your doc indefinitely.

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Last updated Jun 7, 2019

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