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A 40-year-old female asked:

What are possible causes of highly elevated imm levels with low img levels with no monoclonal gammopathy present?

3 doctor answers4 doctors weighed in
Dr. John Goldman
Rheumatology 57 years experience
May not be a problem: This may depend on your genetic background and not be a medical problem. We would need an explanation of your problems, blurred vision, night sweats. Why are you on opiates
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Dr. Ed Friedlander
Pathology 46 years experience
Dr. Goldman is correct. Don't let an abnormal lab distract from a search for the reason for your blurred vision and night sweats. TB and bacterial endocarditis are only two of several concerns.
Jul 27, 2014
Dr. Ed Friedlander
Pathology 46 years experience
Get a consult: A specialist immunologist may be able to address this. I'm concerned right away about a variant of relatively mild immunodeficiency in which there's difficulty switching from IgM to IgG. Rather than trouble you with the details, let me simply suggest that this belongs in the hands of a subspecialist. Best wishes.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Le Wang
Dr. Le Wanganswered
Internal Medicine 38 years experience
Several: Our immune B cells produce IgM fist, then switch to IgG or others by a class-switch process. The defective B cell class-switch can result in high IgM, and low IgG. This could be genetically (hyper IgM syndrome) or viral infection or drugs, or lymphoma, etc.
Created for people with ongoing healthcare needs but benefits everyone.

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Last updated Aug 18, 2019

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