Is it safe to take pimecrolimus in pregnancy?

Unknown: Category c, unknown risk in humans during pregnancy or breast feeding. Animal studies have suggested risks. It is a topical drug but common side effects suggest absorbtion. Risk will have to be weighed against benefits by the patient and her doctor.

Probably: While any drug taken during pregnancy has the potential to negatively affect the fetus, calcineurin inhibitors like tacrolimus and pimecrolimus are considered category c drugs, which means that they have not been associated with fetal loss or birth defects in animal studies. However, category c also means that these drugs have not been well studies in humans, so there may be potential risks.