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A female asked:

Just got perscribed concerta. how many hours after tramadol is it safe to start taking it? i was just recently put back on my add meds. i am a 29 year old female. i have had add my whole life. i also take tramadol for hip pain . more so when i am active

2 doctor answers2 doctors weighed in
Dr. Andrius Baskys
Dr. Andrius Baskysanswered
Geriatric Psychiatry 48 years experience
Both : Both drugs lower seizure threshold, therefore, their interaction is undesirable, as you correctly pointed out. Tramadol elimination from the body primarily depends on the state of your kidneys and liver as well as what other medications you have been taking. Assuming that your liver and kidneys are healthy, and you are not taking any other medications that could impact elimination of tramadol (e.g. Quinidine) the half-life of tramadol will be about 7 hours. A "half-life" is the amount of time during which the concentration of a drug in the body decreases by half. Tramadol has a pharmacologically active metabolite mono-o-desmethyltramadol known as m1. The half-life of m1 in a healthy young person is approximately 7.4 hours. Therefore, a conservative estimation of the time needed to clear your body from tramadol and m1 is: half-life x 4, which is approximately 28-30 hours. However, if your liver is not healthy (e.g. There is liver cirrhosis), the half-life of tramadol and m1 increase to 13 and 19 hours respectively. In that case, your body will be cleared from tramadol in 52 hours and from m1 in 76 hours.
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Dr. Stephen Scholand
Infectious Disease 25 years experience
Tramadol & Concerta: Tramadol is an opioid with analgesic (pain blocking) & serotoninergic (mood altering) effects. Methylphenidate (Concerta) is an amphetamine and acts in the brain as well - essentially 'revving' things up. Having 2 drugs work in the brain could be a set-up for side-effects (SE), such as seizures -rare but serious SE when used in combination. For hip pain an anti-inflammatory is better, i.e. Motrin
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Feb 24, 2018


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