A member asked:

What's the difference between celexa and wellbutrin (bupropion)?

6 doctors weighed in across 3 answers

Mechanism of action: Celexa (citalopram ) is a antidepressant that works mainly on the serotonin metabolism wellbutrin (bupropion) works in the dopaminergic circuit . They can be combined for added effect or decrease of side effects of serotonin related antidepressants such as decresed libido.

Answered 6/28/2017

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Dr. Barbara Srur answered

Specializes in Psychiatry

Effect on the brain: There are 3 main neurotransmitters in the brain. Celexa mainly affects the serotonin circuits. Wellbutrin (bupropion) affects the norepinephrine and Dopamine circuits. Depending on the symptoms, one or other , sometimes both of the medications would be chosen. A psychiatrist is the most knowledgable to make the best selection of treatment.

Answered 4/21/2016

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Dr. Alan Ali answered

Specializes in Psychiatry

Celexa/Wellbutrin: Both are antidepressants. Celexa is a Serotonin reuptake inhibitor used for major depression & anxiety. Wellbutrin (bupropion) is a separate group of antidepressants with more stimulating effects, used more for anergic depression & sometimes to boost treatment of Attention deficit.

Answered 11/4/2018

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