I have been taking seroquel (quetiapine) for depression and sleep issues, how much can i take before it becomes unhealthy?

It depends.: Everyone responds differently to drugs based on body size, metabolism, and other factors, but the maximum recommended dose for most uses of seroquel (quetiapine) involving depression is around 300mg/day total at the high end. For insomnia, usually patients are started at a dose closer to 25-50mg/day. Seroquel (quetiapine) can have several side effects; see your doctor if you are experiencing something concerning.

Varies: The dose of seroquel (quetiapine) that people take will vary, but it is possible to take several hundred milligrams for depressive symptoms. A dose of 400-600mg would not be unusual if needed and if tolerated.