Preferably not: Mucinex (guaifenesin) d contains Guaifenesin Pseudoephedrine 120mg which can raise blood pressure, make you jittery, "hyper" and cause heartburn and constipation. Prednisone 40 mg may worsen the side effects, like high blood pressure, thyroid problem or diabetes. You should rinse y our nose with saline and use a nasal decongestant like oxymetazoline (afrin) for 5 days. Guaifenesin may help (mucinex (guaifenesin) without d).
Answered 1/27/2020
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