Is it normal for 35 y/o non-alcoholic female w/o family history of pkd to develop multiple painful bilateral renal cysts, high urine output & high bp?

See bow: Pkd can occur without known family history as it can be asymptomatic. Cysts can be painful without any reason.

Isolated PKD: PKD is autosomal dominant. One PKD allele is all that is needed to express PKD. Expression is over 90%. What you report is not normal, nor usual. Over 90% of expressed, affected persons have an affected parent. Yet, old data indicate that ~10% of affected persons do not have a parent with expressed PKD. Yet new data reveal that PKD gene mutations do exist in a parent without expression.