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Ballwin, MO
A 59-year-old female asked:

Which is the better steroid replacement, prednidone or cortef (hydrocortisone)? for secondary adrenal insufficiency.

2 doctor answers3 doctors weighed in
Dr. Klaus d Lessnau
Pulmonary Critical Care 37 years experience
Same thing: Depends the dose check with your doc asap.
Dr. Vered Lewy-Weiss
A Verified Doctoranswered
29 years experience
I like Cortef (hydrocortisone) best: For adults it's a personal preference, but Hydrocortisone (cortef (hydrocortisone)) gives more physiologic steroid hormone replacement. Doses much easier to adjust, though trade-off is taking 3 times/day because 1/2 life is shorter than prednisone. Prednisone is much stronger than Hydrocortisone so it's easier to get cushingoid taking it, especially because dose can't be manipulated as finely as with cortef (hydrocortisone).
Last updated Apr 5, 2016


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