Can manic depression or regular depression run in the family?

See Below: There's some evidence that depression and or psychiatric disorders, as well as suicidal behaviors have a familial relationship. As with many things, environment comes into play together with genes. If there are these issues in your family, please find a psychotherapist to help you work through them and create a "crisis card" in case help is needed.

Yes: that can occur. But there is usually a mix of genetics and environment at play. There may be skip generations. Penetrance for genetic predispositions is variable. You might look at a family line and see that one person has unipolar depression, another is bipolar, one has anxiety disorders and another suffers from substance abuse. In other words- it is not as simple as bipolar begets bipolar.

Yes: Much of the time there is s strong family/genetic component of heredity in mental health disorders, which can be cross-generationally traced.