Decongestant?: Zpack (azithromycin) is an antibiotic and does not treat the symptoms of headache- just an underlying infection which may be the cause of the headache. A sinus headache is caused by pressure from congestion in the sinuses. If your blood pressure is fine, a decongestant such as Pseudoephedrine could be taken along with the zpack to relieve the congestion. Ibuprofen can help with pain and inflammati.
Answered 12/29/2016
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