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A 43-year-old member asked:

How do ssris treat depression?

2 doctor answers8 doctors weighed in
Dr. Lisa Saponaro
Clinical Psychology 18 years experience
Placebo effect: Ssris- are selective serotonin reuptake inhibitors. They allow serotonin to stay present in the synapses of the brain for longer periods of time. Serotonin has been shown to be associated with mood and therefore allowing it to be present longer is believed to result in improved mood. However, most research indicates that the majority of improvement is likely placebo for mild/moderate depression.
Dr. Andrew Ho
Psychiatry 30 years experience
Neurogenesis: Ssri antidepressants work by blocking reuptake of serotonin from synapses. Because they have a delayed onset of antidepressant effect (several weeks) relative to speed of blocking serotonin reuptake (several hours), any explanation has to account for this discrepancy. One hypothesis is that there is growth of new neurons in the hippocampus that is responsible for antidepressant effect.

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A 19-year-old member asked:

How can I treat depression?

9 doctor answers18 doctors weighed in
Dr. Jeffrey Barke
Family Medicine 31 years experience
Exercise: Depression can be very serious and sometimes caused by medical illness. See your family doc to get checked out. In addition to prescription medication for depression daily vigorous exercise can help as well as seeing a councilor, reading books about depression, and taking better care of yourself.

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Last updated Mar 28, 2018

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