A member asked:

Loss of feelings and interest for your partner due to depression. which ssri's work the fastest?

10 doctors weighed in across 2 answers

All are similar: The various ssri antidepressants have similar mechanisms of action but differ in serotonergic potency and specificity, length of action, metabolism and--most importantly--efficacy and side effects with any given individual. No valid claim can be made as to the 'fastest-acting'. Some people respond in a week, some in 6-8 weeks, some have an early activating side effect felt as helpful.

Answered 11/7/2016

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Depends: All the ssris are effective for depression however people may have different responses/side effects to the different ssris depending on their symptoms and the medications' side effect.

Answered 10/4/2016

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