A member asked:

Can methotrexate cause depression & appetite increase? most people experience appetite decrease but it seems like mine has increased lol.

2 doctors weighed in across 2 answers

Not necessarily: Answer this i think it depends on what else you have and what else you take. Neither may be related to the methotrexate.

Answered 3/26/2013

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Dr. Alan Ali answered

Specializes in Psychiatry

Methotrexate: Not a reported side-effect. One thought is that it might be working for the illness it is treating (ex. Cancer or autoimmune disease), hence the resultant improvement in appetite. The depression might be the fatigue & dizziness caused by Methotrexate as side-effects.

Answered 6/28/2014

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