A member asked:

Can prednisone and methotrexate make you depressed?

4 doctors weighed in across 3 answers
Dr. Heidi Fowler answered

Specializes in Psychiatry

Use of prednisone: Can cause depression. Methotrexate can cause "moodiness".

Answered 2/24/2018

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Dr. Hamsa Jayaraj answered

Specializes in Internal Medicine

Pred. can cause depr: Prednisone can cause several psychiatric manifestations-depression, psychosis etc etc oral methotrxate does not have any psychiatric side effects.

Answered 1/17/2015

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Dr. Lynne Weixel answered

Specializes in Clinical Psychology

Your condition can!: You must be under care of a doctor (or )a team for whatever you were prescribed these powerful drugs. They do interact to increase side effects but depression is not listed as one. However, serious physical illness is certainly a known cause of depression through a variety of paths. You hurt, worry, experience pressure, confusion, disappointment, fear, etc., etc. A health psychologist can help.

Answered 1/17/2015

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