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A 40-year-old member asked:

What causes low grade liposarcoma to upgrade to high grade liposarcoma?

2 doctor answers6 doctors weighed in
Dr. Murthy Andavolu
Hematology and Oncology 32 years experience
Mutations: Genetic mutation(s) in the tumor can make it grow faster suddenly.
Dr. Sabha Ganai
Surgical Oncology 20 years experience
Hard to say: There are situations when a pathologist reviews the specimen again and finds higher grade "angrier" looking cells in the specimen - leading to an upgrade. There are also situations when a liposarcoma recurs and the new tumor has "de-differentiated" or evolved into an angrier tumor. This can happen with time with certain aggressive liposarcomas.

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Last updated Apr 15, 2013

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