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A member asked:
What causes low grade liposarcoma to upgrade to high grade liposarcoma?
6 doctors weighed in across 2 answers
Mutations: Genetic mutation(s) in the tumor can make it grow faster suddenly.
Answered 1/18/2012
6.3k views
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Hard to say: There are situations when a pathologist reviews the specimen again and finds higher grade "angrier" looking cells in the specimen - leading to an upgrade. There are also situations when a liposarcoma recurs and the new tumor has "de-differentiated" or evolved into an angrier tumor. This can happen with time with certain aggressive liposarcomas.
Answered 4/15/2013
5.2k views
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