A 40-year-old member asked:
What causes low grade liposarcoma to upgrade to high grade liposarcoma?
2 doctor answers • 6 doctors weighed in
Hematology and Oncology 32 years experience
Mutations: Genetic mutation(s) in the tumor can make it grow faster suddenly.
6.3k viewsReviewed >2 years ago
Surgical Oncology 20 years experience
Hard to say: There are situations when a pathologist reviews the specimen again and finds higher grade "angrier" looking cells in the specimen - leading to an upgrade. There are also situations when a liposarcoma recurs and the new tumor has "de-differentiated" or evolved into an angrier tumor. This can happen with time with certain aggressive liposarcomas.
5.2k viewsReviewed >2 years ago
Last updated Apr 15, 2013
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