Is it safe to get a facial while taking prescription acne medications benzoyl peroxide and clindamycin ?

Yes.: This should not be a problem at all. Just remember that if you are on a prescription strength retinoid, you cannot get waxing performed as this can actually remove the topmost layers of skin.

Likely OK: A good spa will have providers who are familiar with common skin agents. I suggest you discuss it with your esthetician before the treatment, and if she/he looks at you with a blank stare, find another provider.