Is there a link between low hdl and accutane?

Indirectly: Accutane incresases levels of a protein called apociii , which is an inhibtior of another protein apocii. Apo cii is the binding site for an important enzyme called lipoprotein lipase, which when acts on triglyceride containing particles removes or hydrolyzes triglycerides (tg's). Too much apociii (via accutane) raises tg's. High tg's are a very common cause of low hdl. Thus Accutane lowers hdl.