Will there ever be a cure for gastroesophageal reflux disease?

Hard to say: This is where medicine is more art than science. If by cure you mean no more heart burn, we are almost there. Reflux, however, is a physiologic event that will happen under many common settings (large meal, carbonation, muscle relaxant, poor gastric emptying / full stomach...). The best reflux rx is actually a combination of wise dietary selection, good lifestyle and medical attn as needed.

There already is!!!: Minimally invasive anti-reflux surgery repairs the failed natural anti-reflux valve at the top of the stomach and cures reflux disease with 95% effectiveness. The most common procedure is called lap nissen fundoplication which involves wrapping the top part of the stomach around itself to create a robust valve that prevents reflux. Experienced surgeons have shown over 10 year durability.