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A 28-year-old female asked:

Are big pathes of hyperpigmentation on the skin common in lupus?

2 doctor answers2 doctors weighed in
Dr. Morris Westfried
Dermatology 48 years experience
Yes: However this is more common in a condition called morphea which is localized scleroderma.
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Dr. Bryan Wu
Dr. Bryan Wuanswered
Pathology 22 years experience
It can happen.: In individuals with lupus and skin involvement, the pattern of inflammation seen microscopically is an interface pattern. Inflammatory cells in this pattern involve the junction of the epidermis and dermis. Melanocytes are located in this area, and the pigmentation of epidermal cells is disrupted. In some individuals, this results in hyperpigmentation; in others, there can be hypopigmentation.
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Last updated Mar 26, 2013
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