A member asked:

Why does methotrexate lose its effectiveness over a long period time?

A doctor has provided 1 answer

Methotrexate : It is not known exactly why Methotrexate sometimes loses its effectiveness. Happily, there are several other options for the treatment of severe psoriasis which may work if and when Methotrexate stops working. Consult with your dermatologist.

Answered 1/18/2021

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