A member asked:

What is the difference between hemoglobin s and hemoglobin a?

6 doctors weighed in across 2 answers

Normal and Abnormal: Hemoglobin consists of two pairs of polypeptides chains. It exists inside the red blood cells ANS is important for oxygen transport. Hemoglobin a is one of the normal hemoglobins and has alpha2/beta2 chains. Hemoglobin s is a mutant hemoglobin responsible for sickle cell trait and disease. Hemoglobin s is poorly soluble when deoxygenated given the red cell the sickle shape.

Answered 11/3/2018

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Dr. Richard Zimon answered

Specializes in Internal Medicine

Hemoglobin s: is the "abnormal" hemoglobin associated with sickle cell disease. Hemoglobin a is normal hemoglobin. Hope this is helpful! Dr Z

Answered 11/3/2018

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