Usually none: Patients with hemoglobin d disease (both copies of the beta-hemoglobin gene carry the mutation) usually have mild anemia and no symptoms. If someone has both hemoglobin d and the mutation for sickle cell disease, they can have health problems. For an excellent overview of hemoglobin d, see: http://www.Stjude.Org/stjude/v/index.Jsp?Vgnextoid=30f0db6324d6f110vgnvcm1000001e0215acrcrd.
Answered 1/25/2014
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