Is remicade (infliximab) safe overall or does it have side effects?

It has side effects: All medicines have side effects. You have to decide if the benefit you will get from it is worth the risk. The risks are well detailed in the package insert. We can't sugarcoat it but we carefully monitor and we try to avoid the side effects. I often recommend a short three month to six-month course to see if the benefit you get is worth the risk.