A member asked:

Is it safe to take benadryl (diphenhydramine) and melatonin?

A doctor has provided 1 answer
Dr. Ralph Morgan Lewis answered

Specializes in Family Medicine

With caution: Although technically no drug-drug interactions are listed for the 2, both cause sedation & might have an additive effect. Be sure how the combination will affect you before operating machinery or driving. People have been cited for dui from Benadryl (diphenhydramine) alone.

Answered 6/24/2014

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Is it okay if to take 2 benadryls (diphenhydramine) and I melatonin?

3 doctors weighed in across 2 answers