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Corpus Christi, TX
A 55-year-old male asked:

is it ok th take benadryl (diphenhydramine) and 1mg of melatonin before bed without side effects?

1 doctor answer1 doctor weighed in
Dr. Dariush Saghafi
Neurology 33 years experience
Side effect possible: Benadryl (diphenhydramine) and melatonin could make a purpose MORE tired and sleepy which could translate into being groggy in the morning thought for all practical purposes, 1 mg. of melatonin is an extremely small amount. Then, again, I don't know anything about your build, your weight, other medications you are taking, etc. etc. so perhaps FOR YOU....1 mg. of melatonin is more than what it may sound.

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A 51-year-old member asked:

Is it safe to take Benadryl (diphenhydramine) and melatonin?

1 doctor answer3 doctors weighed in
Dr. Ralph Morgan Lewis
Family Medicine 38 years experience
With caution: Although technically no drug-drug interactions are listed for the 2, both cause sedation & might have an additive effect. Be sure how the combination will affect you before operating machinery or driving. People have been cited for dui from Benadryl (diphenhydramine) alone.
A 31-year-old member asked:

Is it safe to take Benadryl (diphenhydramine) and melatonin together?

2 doctor answers7 doctors weighed in
Dr. Anthony LaBarbera
Dr. Anthony LaBarbera answered
Pediatrics 28 years experience
Yes: But, if you are taking Benadryl (diphenhydramine) to help with sleep, there are better medications.
A 34-year-old member asked:

Can melatonin and Benadryl (diphenhydramine) be mix and safe to use together?

1 doctor answer3 doctors weighed in
Dr. David Sneid
Endocrinology 41 years experience
Yes: But both have sedative properties and can lead to some hangover effects in the morning if taken for sleep, take as low a dose of melatonin as possible, 90min before desired sleep time.
A 34-year-old member asked:

Is it okay to take melatonin with benadryl (diphenhydramine)?

1 doctor answer2 doctors weighed in
Dr. Bashar Brijawi
A Verified Doctor answered
A US doctor answered Learn more
You can but: The risk of morning sleepiness or hung over will be higher.
A 31-year-old member asked:

Dangerous to use melatonin and diphenhydramine?

2 doctor answers4 doctors weighed in
Dr. Doanh Nguyen, md, faaaai
Allergy and Immunology 14 years experience
No it shouldn't: You can take both together. There should not be any problems taking both medications together even if you use it as sleeping aide. Make sure you don't take more the the recommended otc dose.

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Last updated Jun 24, 2014
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