A member asked:

What does small m protein and igg lambda spike mean?

A doctor has provided 1 answer

Dr. Michael P Vaughn answered

Specializes in Allergy and Immunology

Monoclonal M-spikes : Antibodies such as igg are usually polyclonal. This means that many different b-cells are making antibodty with many different binding specificities. Monoclonal (m-spikes) suggest that the origin of the antibody is from one clone of blood cells, all originating from a sinle progenitor. This could mean a pre-malignant or malignant populations of cell are present.

Dr Ali and 2 doctors agreed

Answered 2/18/2020

5.8k views

Thank

More of what we treat

Allergies

Antibiotics

Asthma

High Blood Pressure

Prescriptions

Type 2 Diabetes

Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.

Get Virtual Care

For Businesses

About Us

HealthTap Online Primary Care Doctors Accepting New Patients

A member asked:

What does small m protein and igg lambda spike mean?

A doctor has provided 1 answer

Dr. Michael P Vaughn answered

Dr Ali and 2 doctors agreed

Related Questions

A member asked:

Protein Monoclonal Band1 A2.1 Discrete band(2.1g/L)in gamma region w/no apparent suppression ofnormal gamma globulins.Serum protein immunofixation show IgG lambda monoclonal protein band in gamma region&2nd trace IgG lambda in late(cathodal)gamma reg?

A member asked:

High IGA (7.09 g/l), and low IGG (3.05) and low IGM (.15). Beta1 globulin is high, beta2 and gamma are low. Protein Monoclonal band is detected type IGA at 8.5 g/l. FLC = high lambda at 33.4mg/l (normal kappa &ratio). Worried until I see hematologist?

A member asked:

Is a free light chain kappa/lambda ratio of 13 relatively high or just a touch high, with abnormal monoclonal protein anti IgG and anti lambda? Under medical care. Just curious before follow up. Not expecting diagnosis. Positive Ana 1:320 homogeneous?

A member asked:

Parents -nh-lymphoma and multiple myeloma. My blood work - "igg lambda monoclonol protein migrating in gamma region. Thoughts?

A member asked:

I have been diagnosed with osteoporosis and my serum protein blood tests have come back showing a monoclonal IGg lambda paraprotein? Could this be due to the osteoporosis in my bones or something serious?

Sponsored Content

People also searched for:

47 yo husband had SPE w/ normal component values but 2 zones of restriction (beta&gamma). IFE w/ IgG lambda m-protein and monoclonal free lambda. Gave value in mg/dL for both monoclonal 1&2. Is the M spike the sum of these 2 values (=266 mg/dL)?

What does an abnormal protein band 1 mean on electrophoresis? Combined with IGG LAMBDA MONOCLONAL PROTEIN DETECTED

I had serum immunofixation. Scared.no monoclonol proteins. But read'"faint igg. Lambda. Cannot be excluded?

Hema repeated bloodwork after monoclonal IGA lambda found. In one month, m-protein went from 8.5 g/l to 11.4. Is this jump significant? Other values remain out of range with IGA high & IGG, IGM low. Low gamma as well. CBC values ok and no BenceJones?

I had an IFE test done. The results stated. One trace IgG Lambda monoclonal protein migrating in the GAMMA region. Reference range: No monoclonal proteins detected. My rheumatologist said that the results were normal but didnt explain the meaning?

Telemedicine

Primary Care

Manage Your Conditions

Women's Health

Children's Health

Men's Health

Senior Health

Wellness, Prevention & Lifestyle

Sexual Health

Mental & Behavioral Health

Travel Medicine

Urgent Care

Didn't find what you're looking for?

More of what we treat

Allergies

Antibiotics

Asthma

High Blood Pressure

Prescriptions

Type 2 Diabetes

For Businesses

Company

Health Content

Join Us

Download HealthTap

Questions?