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A 31-year-old member asked:

what happens at the end of metachromatic leukodystrophy?

1 doctor answer2 doctors weighed in
Dr. Vered Lewy-Weiss
A Verified Doctor answered
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Loss of function: This is a very rare disease, inherited when both parents are usually carriers. Because of the deficient enzyme, arylsulfatase a, patients suffer from a gradual destruction of myelin sheath, the protective covering of nerves. At the end, loss of muscle function, seizures, possibly coma, and mental illness (in older people) prevail. Unfortunately, no cure, though therapies may improve life quality.

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A 41-year-old member asked:

What happens in the end stages of metachromatic leukodystrophy?

1 doctor answer2 doctors weighed in
Dr. Colin Kerr
Family Medicine 44 years experience
Leukodystroph course: Mld is a severe disease that gets worse over time. Eventually people lose all muscle and mental function. Life span varies depending on what age the condition started, but the disease course usually runs 3 - 20 or more years. See: http://www.Ncbi.Nlm.Nih.Gov/pubmedhealth/pmh0002185/.
A 39-year-old member asked:

Are leukodystrophies like metachromatic leukodystrophy (mld) treatable?

1 doctor answer2 doctors weighed in
Dr. Colin Kerr
Family Medicine 44 years experience
Leukodystrophy: There is no cure for mld. Bone marrow transplantation may delay progression of the disease in some cases. Other treatment is symptomatic and supportive. Considerable progress has been made with regard to gene therapy in an animal model of mld. (http://www.Ninds.Nih.Gov/disorders/metachromatic_leukodystrophy/metachromatic_leukodystrophy.Htm).
A 40-year-old member asked:

What occurs at the end stages of metachromatic leukodystrophy?

1 doctor answer1 doctor weighed in
Dr. Ed Friedlander
Pathology 44 years experience
Palliative care: You have my sympathy. My hope is that when the end time comes, the patient will be allowed to go with comfort and dignity. https://behindthezine.wordpress.com/tag/metachromatic-leukodystrophy/.
A 50-year-old member asked:

What is metachromatic-leukodystrophy? What causes it?

1 doctor answer2 doctors weighed in
Dr. Mitzi Scotten
Pediatrics 28 years experience
A genetic disorder: Metachromatic leukodystrophy is an inherited disorder characterized by the accumulation of fats called sulfatides in cells. This accumulation especially affects cells in the nervous system that produce myelin, the substance that insulates and protects nerves This is a link to the genetic website with more information http://ghr.nlm.nih.gov/condition/metachromatic-leukodystrophy
A 49-year-old member asked:

What is metachromatic leukodystrophy?

1 doctor answer2 doctors weighed in
Dr. Alan Ali
Dr. Alan Ali answered
Psychiatry 32 years experience
MLD: Is a lysosomal storage disease affecting myelin growth, the insulator of nerve fibers, affecting lipid metabolism. It leads to progressive dementia in adults.

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Last updated Mar 26, 2013

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