A member asked:

What is the difference between chlorhexidine digluconate and chlorhexidine gluconate?

5 doctors weighed in across 4 answers
Dr. Brian Dorfman answered

Specializes in Oral and Maxillofacial Surgery

Not much: They work the same way, one product has a slight difference in chemical structure.

Answered 8/9/2017

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Dr. Michael Lebowitz answered

Specializes in Dentistry

Chlorhexadine: From researching this question it seems that the active ingredient in the dental rinse is Chlorhexidine gluconate the reference to the digluconate appears in the Periochip form. I do not see the digluconate as the active ingredient in the products we use in dentistry.

Answered 4/18/2016

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I believe: Chlorhexidine gluconate (peridex, etc) is the preferred formulation (typically as a 0.12% solution rinse). The digluconate version is typically available in stronger concentrations, and probably have an application, but not used in my practice.

Answered 9/22/2017

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Yes: Chlorhexidine digluconate is a much stronger antimicrobial than the gluconate form.

Answered 8/20/2019

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