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A 41-year-old member asked:

What is the difference between chlorhexidine digluconate and chlorhexidine gluconate?

4 doctor answers5 doctors weighed in
Dr. Brian Dorfman
Oral and Maxillofacial Surgery 20 years experience
Not much: They work the same way, one product has a slight difference in chemical structure.
Dr. Michael Lebowitz
Dentistry 34 years experience
Chlorhexadine: From researching this question it seems that the active ingredient in the dental rinse is Chlorhexidine gluconate the reference to the digluconate appears in the Periochip form. I do not see the digluconate as the active ingredient in the products we use in dentistry.
Dr. Behram Dalal
32 years experience
I believe: Chlorhexidine gluconate (peridex, etc) is the preferred formulation (typically as a 0.12% solution rinse). The digluconate version is typically available in stronger concentrations, and probably have an application, but not used in my practice.
Dr. Morey Furman
38 years experience
Yes: Chlorhexidine digluconate is a much stronger antimicrobial than the gluconate form.

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Last updated Aug 20, 2019
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