Left untreated, does cushing's disease impact life expectancy? how? after 4 failed surgeries, i am considering forgoing tx but want to be informed.ty!

Yes it does: Hi. I'm so sorry. Cushing's is a very difficult disease, and surgery is all too often not curative. The post surgical options include: 1) medical; a) mifepristone, a cortisol receptor antagonist, b) pasireotide, a somatostatin analog that reduces tumor size and ACTH secretion, c) keotoconazole, a steroidogenesis inhibitor that blocks cortisol synthesis, and 2) radiation of pituitary (gamma knife)