Is it safe to take dyphenhydramine n psuedoepihdrine in 2nd trimester for flu?

Know this site: http://www.drugs.com/pregnancy-categories.html. It is classified as Pregnancy Risk Class B, ie there has been no evidence of associated risk & is generally considered not to be harmful to the unborn fetus. It doesn't cross over the maternal-fetal boundary of the placenta. That said, it is secreted into breast milk & is considered unsafe for newborns once outside of the womb due to excess sedation.

Yes : Those medications are safe for use. Remember to get your flu shot next year. Tamiflu (oseltamivir) is Also for safe for use and is more effective.