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A 44-year-old member asked:

What is the most common genetic disorder in the u.s.?

1 doctor answer4 doctors weighed in
Dr. Richard Roberts
Pediatrics 46 years experience
Too complex to answer: There are Mendelian disorders: X-linked recessive, X-linked dominant, autosomal dominant, and autosomal recessive. There are genetic disorders caused by abnormal amounts of chromosomal material: trisomies, deletions, and duplications. The largest group are disorders in which there is clearly a genetic component, but non-genetic factors are also important. No easy answer.
Dr. Richard Roberts
Pediatrics 46 years experience
Provided original answer
I should also mention the great importance of epigenetic factors: those factors which can interfere with normal genetic expression--such as turning off a particular gene which should be functioning, or vice versa.
Nov 22, 2016

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A 36-year-old member asked:

What is the least common genetic disease that is seen in the U.S.?

1 doctor answer2 doctors weighed in
Dr. Richard Roberts
Pediatrics 46 years experience
Unknown: Some are rarer than one in 100,000. We are continually finding new genetic disorders and we may have no clue with regard to how frequent they are. Dozens of severe multiple malformation syndromes exist which are striking but none of the world's geneticists have a clue with regard to what causes them. How do you estimate frequency of a single case in the world's medical literature?
A 40-year-old member asked:

Can you tell me about the most common genetic disorder?

2 doctor answers2 doctors weighed in
Dr. Anna-Kaisa Niemi
Clinical Genetics 16 years experience
Thalassemias: Alpha and beta thalassemias are estimated to be the most common genetic conditions. Who has a nice article and list of common genetic conditions in the world, here link for your convenience: http://www.Who.Int/genomics/public/geneticdiseases/en/index2.Html.
A 51-year-old member asked:

Which genetic disorders are most common and least common?

1 doctor answer1 doctor weighed in
Dr. Dan Fisher
Internal Medicine 27 years experience
Depends: on how strictly you define things. The big ones are: familial hyperlipidemia Cystic Fibrosis Thalassemia Muscular Dystrophies Down's Syndrome Fragile X Hemochromatosis Sickle Cell Disease Alpha 1 antitrypsin deficiency. There are many many diseases of which there are only a few in the whole world and there are probably a few we haven't seen yet.
A 30-year-old member asked:

What are the most common genetic disorders?

1 doctor answer1 doctor weighed in
Dr. Gurmukh Singh
Pathology 49 years experience
It depends on what: You call genetic. Almost all diseases are a combination of genes and environment. Consult the following site of a list of common single gene defects.http://archive.blisstree.com/feel/ten-most-common-inherited-genetic-diseases/.

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