What are the safest cold and allergy medicines i can use while pregnant?

See Below: Claritin (loratadine) and Zyrtec (cetirizine) are pregnancy category B medications which means that animal reproduction studies have failed to demonstrate a risk to the fetus. I frequently use these medications with my pregnant patients. Allegra (fexofenadine) and many of the ingredients in cough meds are category C so avoid these medications if possible. If concerned, talk to OB/GYN about specific medications.

Most AHs and NS: The 2008 updated guideline on rhinitis noted that studies on over 200000 pregnant women failed to show any congenital defect from antihistamines. Nasal steroids are also safe although budesonide is the only one studied and consider Cat. B for pregnancy. In the 1st trimester, avoid Benadryl (diphenhydramine) or hydroxyzine since this is the period congenistal defect occurs. Avoid oral decongestant as well.