It's Controversial.: Multiple studies have been done to answer this question, and some have shown a decrease in C. difficile, while others have shown no benefit. Because the risk of side effects of probiotics is generally low (but not zero) I usually recommend to take them if you have had a previous episode of C. difficile or if you have other risk factors for it. Otherwise, there is likely not to be much benefit.
Answered 7/26/2018
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