If i take probiotics with clindamycin will that reduce the risk of side effects? (ex: c diff)

It's Controversial.: Multiple studies have been done to answer this question, and some have shown a decrease in C. difficile, while others have shown no benefit. Because the risk of side effects of probiotics is generally low (but not zero) I usually recommend to take them if you have had a previous episode of C. difficile or if you have other risk factors for it. Otherwise, there is likely not to be much benefit.