No: Not if you took 2 plain or even extra-strength acetaminophen, and even if you got drunk. However, REGULAR use of tylenol, even in therapeutic doses (2 grams or less per day, 4 grams at MOST), together with REGULAR use of alcohol, can cause toxicity and damage the liver. If you take a VERY large amount of tylenol, alcohol can make that more toxic and likely to cause liver damage.
Answered 11/10/2014
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