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A 39-year-old member asked:

How do antidepressant drugs affect the nervous system?

1 doctor answer1 doctor weighed in
Dr. John Moranville
Psychiatry 37 years experience
Which antidepressant: Be more specific. Paxil, Prozac, celexa, lexapro, etc are SSRI and increase serotonin. SNRI like cymbalta, Effexor, (venlafaxine) etc increase both serotonin and norepinephrine. Wellbutrin increases dopamine levels. Older antidepressants like amitriptyline, etc increase just norepinephrine. Mirtazepine has a more complex mechanism. There are some I have not mentioned but those are the main mechanisms

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Last updated Nov 21, 2014

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