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A female asked:

is it safe to take wellbitrin xl, buspar, (buspirone) and 5htp together? trying to help depression/obsessive thinking and anxiety. thanks!

4 doctor answers7 doctors weighed in
Dr. Heidi Fowler
Psychiatry 25 years experience
Possibly: But why aren't you taking a prescription medication instead of 5 htp? When involved in polypharmacology it is much safer to ensure that your prescriber is aware of, and helping to supervise use of all of your medications. Did your medical provider recommend the 5htp?
Dr. Lynne Weixel
Clinical Psychology 36 years experience
Not a good mix: There is an increased risk of serotonin when you combine 5-HTP w/ BuSpar (buspirone). That's not a good risk to take unless it is essential and will be carefully monitored by your doctor. Do try to fine another approach - consider a good psychotherapist w/ experience in treating your issues. CBT really can be effective to optimize mediction outcomes. Best!
Dr. Paul Grin
Pain Management 36 years experience
Great combo: for depression, OCD and anxiety management and no interactions with wellbutrin xl and buspar (buspirone). However, always ask your doctor about anything that seems unclear. Take care.
Dr. David Masiello
Hematology and Oncology 18 years experience
Yes: It would appear that there are no drug drug interactions with this combination, although 5-HTP is an OTC formulation. It woul dbe best to ask your pharmacist regarding drug drug interactions.

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