Which pain reliever doesn't affect your liver?

Liver & Pain Relieve: Hello. Most meds used to treat pain whether narcotics or non-narcotics are metabolized heaviest through the liver. If not through the liver, then metabolism is through the kidney (most NSAIDs like Ibuprofen, Aleve, Motrin, Mobic, (meloxicam) Celebrex, etc.). Some meds are metabolized through both liver & kidney. Topical meds have the least side effects on the liver AND kidneys (lidocaine, diclofenac, etc.)

Opioids: As opposed to many other medications used in pain, opioids do not cause organ damage with long-term use. But because of concerns about tolerance, physical dependence and addiction, many doctors are still reluctant to prescribe opioids for chronic pain.