What should be done if my sister has really bad eczema?

See specialist: For refractory eczema there are various treatment that you might not have tried that could improve your symptoms. Higher dose topical corticosteroid ointments, better skin hygiene, more frequent moisturization, chlorine baths, wet wraps, phototherapy, oral antibiotics, calcium/vitamin D supplementation, or more aggressive systemic medications like anti-inflammatories or immune-modulators.