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A 45-year-old member asked:

What is immunoglobulin diversity generated by?

1 doctor answer2 doctors weighed in
Dr. Amit Golding
20 years experience
Combinatorial: The genes that encode our antigen receptors (immunoglobulin and T cell receptors) are made up of hundreds of gene segments. These "V-D-J" segments recombine in potentially millions of combinations so that each immune cell has one final version that makes a unique receptor. This process is random but if the cell encounters its antigen it will be activated and can turn into a "memory" cell.

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Last updated Nov 27, 2014

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