How to treat mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question.

Medications can help: Cutaneous (skin-only) mastocytosis can be treated with antihistamines, singulair, (montelukast) and topical cromolyn if the itching, etc., is problematic. The same meds can help systemic mastocytosis, with swallowed cromolyn for GI symptoms. Epinephrine can help resolve anaphylaxis if that occurs. Avoid codeine/opiates and other meds that directly activate mast cells. Talk with a specialist for more info.