In general, when is it appropriate to call your doctor? i've heard they're really busy, so i'm not sure if you're supposed to wait for an appointment.

New/worsening issues: With concerning new or worsening symptoms, you should get in touch with your physician. He/she would likely appreciate that you called earlier when he/she can intervene, vs. waiting, when the symptoms may be harder to treat. He/she should have an answering service for nights/weekends. http://www.cfah.org/prepared-patient/prepared-patient-articles/chronic-conditions-when-do-you-call-the-doctor