Does zoloft (sertraline) calm down the nervous system ?

Sertraline mechanism: Zoloft (sertraline) does not calm the entire nervous system, it specifically works a part that uses serotonin. It is a serotonin re-uptake inhibitor. This is meant to change levels of a neurotransmitter involved in the feelings of depression and anxiety. It does not affect many other neurotransmitters in the nervous system, such as dopamine, glutamate, etc.