NO: Zoloft (sertraline) , antidepressants in general, leave no telltale "marks" on common imaging studies (ct, mri) there maybe brief changes in certain receptors, but this would require very sophisticated imaging that would only be used in a research trial. Over time receptors are "recycled", it is doubtful that the new receptors would show evidence of medication use.
Answered 5/1/2016
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